Single Crystal Structures From Powders

Using MicroED, a three-dimensional electron diffraction method, single crystals of all classes below one micron in size can be studied. The XtaLAB Synergy-ED offers the ability to determine the single crystal structure from a single grain from powder samples. In fact, one can determine the single crystal structure of multiple compounds present in a single powder sample.

There are two well-characterized polymorphs of acetaminophen with known single crystal structures. In this presentation we will explore the case of a third polymorph of acetaminophen generated in an XRD-DSC experiment with a structure determined by MicroED. This result is a major step in understanding the properties of acetaminophen and demonstrates the potential to solve many more unsolved problems in structural science.